Charts Showing Anticancer effect of polysaccharide extracted from Agaricus Blazei Burrill against Meth A fibroblastemic sarcoma

Agaricus Max
Tables and Charts
Article 4

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Figure 1

Inhibition of diabetes development in NOD mice
(Type I diabetic disease model) from the experiment of Hitoshi Ito and Keishiro Shimura or Mie University

Experimental group: 5 mice fed with:

Mouse food powder: 90%
Flour 5%
Agaricus Blazei Murrill (powder): 5%

Experiment

Control group: 5 mice fed with:

Mouse food powder: 95%
Flour 5%

One mouse died in week 15 and another in week 33. One of the remaining 3 mice became diabetes positive, but the 3 mice are alive as of week 40.

Result

All mice died in weeks 15 - 17 due to development of diabetes.

Figure 2

Anticancer effect of polysaccharide extracted from Agaricus Blazei Burrill against
Meth A fibroblastemic sarcoma

No. of days after tumor transplantation

FIII-2-b: Polysaccharide extracted from Agaricus Blazei Murrill
5-FU: Pyrimidine metabolism antagonizing antitumor medicine
Control: Control group

Figure 3

Steroids dissociated from Agaricus Blazei Murrill

ß Synthesized

Source:
H. Kawagishi
R. Katsumi
T. Sazawa
T. Mizuno
T. Hagiwara and
T. Nakamura
"Phytochemistry,
27, 2777" (1988)

Figure 4

ATOM's effect to help recover from the inhibition of reticuloendothelial system function causedby anticancer medicines (under Ehrlich ascites and gallbladder carcinoma)

MMC: Mitomycin C
CY: Cyclophosphamide
5-FU: Fluorouracil

Figure 5

Effect of antitumor polysaccharides extracted from Agaricus Blazei Murrill to T- Lymphocyte (lymph cell)

MetA fibroblastemic sarcoma was transplanted to subcutis of mice. Antitumor polysaccharides extracted from Agaricus Blazei Murrill was administered for 21 days, starting from 24 hours after the transplantation. Spleens of the mice was removed 24 hours after the last administration and ratio of L3T4+, asialo GM1+ and Lyt12+ cells was measured by flowcytometry. Each group consisted of 10 mice.

Normal mice

Mice with gallbladder cancer

Mice with gallbladder cancer administered with polisaccharides

* P<0.05 (Statistically significant in comparison with normal mice administered with physiological saline only)

= P<0.05 (Statistically significant in comparison with mice with gallbladder cancer administered with physiological saline only)

Figure 6

Anticancer effect of Agaricus Blazei Murrill's lipid section against Ehrlich ascites cancer Lon-gevity rate (%)

·—· Control group
x—x Group administered with 300mg/kg of lipid section
o—o Group administered with 150mg/kg of lipid section

No. of days after cancer transplantation

Figure 7

ATOM's effect to activate reticuloendothelial system function
(under Ehrlich ascites and gallbladder cancer)
Phagocytic Index [K]

Ehrlich ascites cancer was transplanted to male mice of ICR family. Each medicine was administered for 10 consecutive days, starting from 24 hours after the transplantation. Phagocytic Index [K] was measured 24 hours after the final administration.
PS-K: Polysaccharide extracted from trametes versicolor (mushroom).

Figure 8

Effect of ATOM and AB-P (polysaccharide extracted from fruit body of Agaricus Blazei Murrill) to organ weight (under Ehrlich ascites and gallbladder cancer)

Relative organ weight (%) after experiment

Figure 9

Effect of ABWE (Hot water extract of Agaricus Blazei Murrill) to inhibit histamine contraction of intestine piece removed from a guinea pig

Figure 10

Composition of fatty acid of Agaricus Blazei Murrill